
We are Redefining Drug Discovery for Disordered Proteins
Our Mission is to usher in a new wave of transformational precision therapies for aggressive cancers with limited treatment options.
Our strategy is rooted in causal human biology—focusing only on targets where function is unequivocally linked to disease.
Leadership Team







Board of Directors










Stuart Hughes, PhD
Stuart has over 25 years experience in biomedical research conducted across a range of therapeutic areas and in both academic and industrial contexts. His previous role was as CEO of Pathios Therapeutics, a company targeting the proton sensing GPCR, GPR65, with small molecule inhibitors for applications in immuno-oncology and immunology. In this role he led the company from initial hit finding through to clinical development in oncology, securing investment from Bristol Myers Squibb along the way as part of a Series B capital raise. He is also co-founder of ThirtyFiveBio, a company developing genetically-informed precision treatments for digestive system disorders. Prior to Pathios, Stuart was Senior Director at Vertex Pharmaceuticals where he led multiple drug discovery projects in the specialty disease space. He also spent several years at Eli Lilly working across the neuroscience portfolio. Initially trained in mathematics, engineering and neurobiology, Stuart has published extensively on the cellular and network mechanisms of physiological and pathological brain rhythms, making key contributions to the understanding slow sleep waves and the enigmatic human alpha rhythm. He holds a PhD in Neuroscience from Cardiff Unversity as well as an MSc in Electronic Engineering and a BSc in Pure and Applied Mathematics.


Olivier Corminboeuf
Head of Drug Discovery
Prior to joining Nuage, Olivier was the Head of Medicinal Chemistry group at Idorsia where he led the Chemistry Oncology that delivered several pre-clinical candidates, including an EP2/EP4 dual antagonist that entered clinical development. Prior to this, in his work as project leader at Actelion, Olivier participated in the discovery of 4 compounds which entered clinical development, including the first FPR2 modulator that brought the concept of the resolution of inflammation into the clinic. Olivier holds a PhD from the University of Fribourg.


Mateusz Biesaga
Founder and Head of Technology


Jordina Guillén, PhD
Head of Science


Andri Leonidou, PhD
Head of BI and Corporate Affairs


Julia Pi
Operations and Communications Manager
Julia joined Nuage Tx in 2025 as the Operations & Communications Manager. Before joining Nuage, Julia project managed the initial setup and operations of the Barcelona Collaboratorium for Modelling and Predictive Biology, a joint initiative between EMBL Barcelona and the Centre de Regulació Genòmica (CRG). Prior to that, she was responsible for delivering multimillion-pound capital projects funded by UKRI at EMBL-EBI. Before, she also coordinated the delivery of the IT transformation at Churchill College (University of Cambridge). Julia holds a master’s degree in Political Communication from Cardiff University and a bachelor’s degree in Political Science and Public Administration from Pompeu Fabra University (UPF).


Vanessa Malier
Chair of the Board


Stuart Hughes
Chief Executive Officer
Stuart has over 25 years experience in biomedical research conducted across a range of therapeutic areas and in both academic and industrial contexts. His previous role was as CEO of Pathios Therapeutics, a company targeting the proton sensing GPCR, GPR65, with small molecule inhibitors for applications in immuno-oncology and immunology. In this role he led the company from initial hit finding through to clinical development in oncology, securing investment from Bristol Myers Squibb along the way as part of a Series B capital raise. He is also co-founder of ThirtyFiveBio, a company developing genetically-informed precision treatments for digestive system disorders. Prior to Pathios, Stuart was Senior Director at Vertex Pharmaceuticals where he led multiple drug discovery projects in the specialty disease space. He also spent several years at Eli Lilly working across the neuroscience portfolio. Initially trained in mathematics, engineering and neurobiology, Stuart has published extensively on the cellular and network mechanisms of physiological and pathological brain rhythms, making key contributions to the understanding slow sleep waves and the enigmatic human alpha rhythm. He holds a PhD in Neuroscience from Cardiff University as well as an MSc in Electronic Engineering and a BSc in Pure and Applied Mathematics.


Xavier Salvatella
Founder


Maina Bahman
Sofinnova Partners


Clara Campas
Asabys Partners


Francesc Aranega
Secretary


Denes Hnisz
Founder and Observer


Anna Bellmunt
Asabys Partners, Observer