Making the impossible possible.
Unlocking the druggability of intrinsically disordered proteins to deliver a new wave of transformative cancer therapies.
About
We are committed to ushering in a new wave of transformational precision therapies for aggressive cancers
Targeting Disordered Proteins in Cancer
A large proportion of the human proteome contains proteins that exhibit high levels of intrinsic structural disorder and are therefore not amenable to conventional drug discovery.
40%
of human proteins contain intrinsically disordered regions (IDRs)
This is especially true in cancer where a host of highly-prized oncogenic transcription factor targets currently sit beyond the reach of traditional approaches.
Nuage is pioneering a whole new type of drug discovery
By leveraging the natural ability of disordered proteins to form transient self-assembled higher-order structures, we are opening up a whole treasure trove of oncology targets for therapeutic targeting.
We are only just getting started
Beyond oncology, structural disorder plays a key role in a range of other key therapeutic areas, including neurodegenerative diseases, autoimmune disorders and many more. Reach out to learn more about our technology.